Ref: Amyloid Beta Peptide Is Released during Thrombosis in the Skin
Lilia Y. Kucheryavykh , Yuriy V. Kucheryavykh , A. Valance Washington and Mikhail Y. Inyushin, Int. J. Mol. Sci. 2018, 19(6), 1705; https://doi.org/10.3390/ijms19061705
While it is known that amyloid beta (Aβ) deposits can be found in different tissues of both Alzheimer’s disease (AD) patients and healthy individuals, there remain questions about the physiological role of these deposits, the origin of the Aβ peptide, and the mechanisms of its localization to the tissues. Applying immunostaining with specific antibodies and ELISA for the Aβ40 peptide, we established that there was release of the peptide in the skin during local experimental photothrombosis in mice. We found that Aβ peptide release was concentrated near the dermal blood vessels in thrombotic skin. We also studied whether the released peptide can affect microorganisms. Application of a solution of Aβ40 at a relatively low concentration (4 µM) to the external membrane of yeast cells significantly augmented membrane conductance while showing no visible effect on mouse host cells. Our data presented in this article suggest that Aβ release is a normally occurring event in the skin, which occurs as often as clotting when skin is damaged. We also propose that Aβ release may serve as part of a natural defense against infection.
Key words: natural antibiotic/Aβ40 peptide/ skin/ thrombosis